Multiple Pathways Differentially Regulate Global Oxidative Stress Responses in Fission Yeast
نویسندگان
چکیده
منابع مشابه
Oxidative stress response pathways: Fission yeast as archetype.
Schizosaccharomyces pombe is a popular model eukaryotic organism to study diverse aspects of mammalian biology, including responses to cellular stress triggered by redox imbalances within its compartments. The review considers the current knowledge on the signaling pathways that govern the transcriptional response of fission yeast cells to elevated levels of hydrogen peroxide. Particular attent...
متن کاملGlobal transcriptional responses of fission yeast to environmental stress.
We explored transcriptional responses of the fission yeast Schizosaccharomyces pombe to various environmental stresses. DNA microarrays were used to characterize changes in expression profiles of all known and predicted genes in response to five stress conditions: oxidative stress caused by hydrogen peroxide, heavy metal stress caused by cadmium, heat shock caused by temperature increase to 39 ...
متن کاملrole of oxidative stress response and trehalose accumulation in the longevity of fission yeast
conclusions our results demonstrated no significant correlation between the ird5 lifespan and the trehalose concentration. likewise, the correlation between lifespan extension, trehalose accumulation, and cellular resistance to hydrogen peroxide was not significant. results the lifespan of the ird5 mutant was significantly longer that of either the ird11 mutant or the wild type cells. under rep...
متن کاملGlobal gene expression responses of fission yeast to ionizing radiation.
A coordinated transcriptional response to DNA-damaging agents is required to maintain genome stability. We have examined the global gene expression responses of the fission yeast Schizosaccharomyces pombe to ionizing radiation (IR) by using DNA microarrays. We identified approximately 200 genes whose transcript levels were significantly altered at least twofold in response to 500 Gy of gamma IR...
متن کاملMultiple Pathways Regulate Minisatellite Stability During Stationary Phase in Yeast
Alterations in minisatellite DNA repeat tracts in humans have been correlated with a number of serious disorders, including cancer. Despite their importance for human health, the genetic factors that influence minisatellite stability are not well understood. Previously, we identified mutations in the Saccharomyces cerevisiae zinc homeostasis genes ZRT1 and ZAP1 that significantly increase the f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2008
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e07-08-0735